Michelangelo, ocular bulb, retina and the Creator.

We are reporting on the recent description published1 in this journal that describes the interesting perspective for previous descriptions2 of the fresco Creation of the Sun, Moon and Plants of the Michelangelo Bounarroti (1475-1564). However, we have a slightly different perspective, in relation to the optic nerves. According to this description1, the nerves would be represented by the heels/feet of the Creator. In our understanding, the heels/feet would be the retina forming part of the ocular bulb (Figure), because when the execution of the fresco, it was already known the relationship between the optic nerve and the ocular bulb2. Besides these anatomical similarities, we can say that both the foot sole somatosensation as visual sensory feedback networks plays a critical role among the active feedback loops that contribute to the control of standing and walking3,4. Of course, at the time of the Michelangelo there was still no proper knowledge of neuronal interactions currently recognized between somatosensory systems, visual, vestibular, numerous brain regions, and the musculoskeletal5. However, we infer that Michelangelo, being a student of Anatomy and Physiology, already knew that the function of heels/feet on the perception of the environment is very similar to the perceptual function of the retina; and this may indeed have influenced Michelangelo in creating this fresco. In addition, the fresco own name: Creation of the Sun, Moon and Plants in the report is words like sun = light that is perceived and processed by the retina.